Shocking, I know, but a sixth outing for super agent Sam Fischer is in development right this second at Ubisoft Toronto. Assassin's Creed producer Jade Raymond has taken the reins of the series, which if you've played any of the AC games you know bodes quite well for Mr.Fischer.
Ubisoft expects to balloon up, staff-wise, and grow to around 800 staffers for the remainder of the project. No word yet on storyline or release date but of you ask me we probably won't see anything until e3.